Motherhood Makes Beyonc? Feel ?More Beautiful Than Ever?

"I feel more beautiful than I've ever felt because I've given birth," says PEOPLE's 2012 World's Most Beautiful Woman. "I have never felt so connected, never felt like I had such a purpose on this earth."

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HP Envy 4 shows up for pre-order on HP's China site, priced as low as 5,499 yuan

A few days ago, HP accidentally listed the unannounced Envy 4 and 6 on a support page within its American website. Fast forward to today, and the company's Chinese site is following in similar footsteps -- though, this time around exposing a couple more details. HP's online shop in China shows a total of six different Envy 4 models, starting with the 1005tx / 1019tx, followed by the mid-level 1004tx / 1021tx and ending with what appears to be the higher-end Ultrabooks: Envy 4-1006tx and 1021tx, which are both priced at 6,299 yuan (around $1,000). As expected, the pair sitting at the bottom of the pile is the lesser-specced of the bunch, revealing an Intel Core i3-2367M CPU, while the top-shelf machine (1021tx) is listed as sporting a Core i5-2467M. Taking into consideration all the recent leaks, it's now only a matter of time before Meg Whitman & Co. make these 14-inch skinny laptops an "official" reality. Until then, those living in China can try and pre-order one of these by pointing your browser toward the source link below.

HP Envy 4 shows up for pre-order on HP's China site, priced as low as 5,499 yuan originally appeared on Engadget on Wed, 25 Apr 2012 11:39:00 EDT. Please see our terms for use of feeds.

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Gatekeeper of brain steroid signals boosts emotional resilience to stress

ScienceDaily (Apr. 23, 2012) ? A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania.

Glucocorticoids are natural steroids secreted by the body during stress. A small amount of these hormones helps with normal brain function, but their excess is a precipitating factor for stress-related disorders.

Glucocorticoids exert their effects on mood by acting on receptors in the nucleus of emotion-regulating neurons, such as those producing the neurotransmitter serotonin. For years, researchers have searched for ways to prevent deleterious effects of stress by blocking glucocorticoids in neurons. However, this has proved difficult to do without simultaneously interfering with other functions of these hormones, such as the regulation of immune function and energy metabolism.

In a recent Journal of Neuroscience paper, the lab of Olivier Berton, PhD, assistant professor of Psychiatry, shows how a regulator of glucocorticoid receptors may provide a path towards resilience to stress by modulating glucocorticoid signaling in the brain. The protein HDAC6, which is particularly enriched in serotonin pathways, as well as in other mood-regulatory regions in both mice and humans, is ideally distributed in the brain to mediate the effect of glucocorticoids on mood and emotions. HDAC6 likely does this by controlling the interactions between glucocorticoid receptors and hormones in these serotonin circuits.

Experiments that first alerted Berton and colleagues to a peculiar role of HDAC6 in stress adaptation came from an approach that reproduces certain clinical features of traumatic stress and depression in mice. The animals are exposed to brief bouts of aggression from trained "bully" mice. In most aggression-exposed mice this experience leads to the development of a lasting form of social aversion that can be treated by chronic administration of antidepressants.

In contrast, a portion of mice exposed to chronic aggression consistently express spontaneous resilience to the stress and do not develop any symptoms. By comparing gene expression in the brains of spontaneously resilient and vulnerable mice, Berton and colleagues discovered that reducing HDAC6 expression is a hallmark of naturally resilient animals. While aggression also caused severe changes in the shape of serotonin neurons and their capacity to transmit electrical signals in vulnerable mice, stress-resilient mice, in contrast, escaped most of these neurobiological changes.

To better understand the link between HDAC6 and the development of stress resilience, Berton and colleagues devised a genetic approach to directly manipulate HDAC6 levels in neurons: Deletion of HDAC6 in serotonin neurons -- the densest HDAC6-expressing cell group in the mouse brain -- dramatically reduced social and anxiety symptoms in mice exposed to bullies and also fully prevented neurobiological changes due to stress, fully mimicking a resilient phenotype.

Using biochemical assays, Berton's team showed it is by promoting reversible chemical changes onto a heat shock chaperone protein, Hsp90, that HDAC6 deletion is able to literally switch off the effects of glucocorticoid hormones on social and anxiety behaviors.

Chaperones are proteins that help with the folding or unfolding and the assembly or disassembly of protein complexes. The way in which glucocorticoid receptor chaperoning and stress are linked is not well understood. Yet, genetic variations in certain components of the glucocorticoid receptor chaperone complex have been associated with the development of stress-related disorders and individual variability in therapeutic responses to antidepressants.

"We provide pharmacological and genetic evidence indicating that HDAC6 controls certain aspects of Hsp90 structure and function in the brain, and thereby modulates protein interactions, as well as hormone- and stress-induced glucocorticoid receptor signaling and behavior," explains Berton.

Together, these results identify HDAC6 as a possible stress vulnerability biomarker and point to pharmacological inhibition of HDAC6 as a potential new strategy for antidepressant interventions through regulation of Hsp90 in glucocorticoid signaling in serotonin neurons.

Co-first-authors are Julie Espallergues and Sarah L. Teegarden, along with Avin Veerakumar, Janette Boulden, Collin Challis, Jeanine Jochems, Michael Chan, Tess Petersen, Chang-Gyu Hahn, Irwin Lucki, and Sheryl G. Beck, all from Penn. Other authors are Evan Deneris, from Case Western Reserve University, Cleveland, Ohio, and Patrick Matthias, Miescher Institute for Biomedical Research, Basel, Switzerland.

This work was funded by the National Institute of Mental Health grants MH087581 and MH0754047 and grants from the International Mental Health Research Organization and the National Alliance for Research on Schizophrenia and Depression.

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The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania, via Newswise.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Hugh Grant Talks Korean Slave-Owner Role In 'Cloud Atlas'

Leave it to the Wachowskis to end their four-year-long hiatus from Hollywood with a movie as crazy and complex as "Cloud Atlas." The adaptation of David Mitchell's novel had stars like Susan Sarandon thinking it was "impossible" to make, yet she seemed pretty confident about the finished product. Hugh Grant told MTV News in a [...]

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HGTV's Carter Oosterhouse's Tips For Your Home Renovations!

In Touch caught up with Carter Oosterhouse, star of HGTV?s Million Dollar Rooms today. We asked the hunk how the everyday person can add a million-dollar feel to their home rennovations without dropping serious $$$$. Here are some of his tips.

1. Always have a plan of attack ? wasting time is wasting money.
2. Consider the layout and flow of your space.
3. Color can be your best friend or you biggest enemy?the right color can change the entire look and feel of a space.
4. Use low flow fixtures ? they make a difference.
5. Marble and Granite countertops are not your only choices. There are more alternative products on the market today than ever before?they give the same expensive look without the price tag.
6. Sweat the small stuff. Accents and accessories really complete a room, so take your time.
7. Plan on going over budget by 10%.
8. Good lighting can make all the difference. Add dimmer switches ? think about some of your favorite spaces and places and what they have in common ? lighting is key.
9. Hardwood flooring will last a lifetime and uses 20% less water than most flooring products to manufacture. Be Green when you can!
10. Know what you?re capable of and what a pro should do. It will cost more to re-do something.

ABOUT HGTV MILLION DOLLAR ROOMS
Million Dollar Rooms with Carter Oosterhouse gives viewers an all-access pass into some of the most extravagant and expensive rooms in the world. The new season premieres Tuesday, April 24th at 8:30pm EST.

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Biotech Company Blamed for Bee Collapse Buys Leading Bee Research Firm [Bees]

Monsanto, the biotech company whose proprietary genetically modified corn has been fingered as the possible culprit in the collapse of the bee population, has gone ahead and purchased Beelogics, a research firm committed to "restoring bee health and protecting the future of insect pollination." More »

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Information Technology Computer Certification Resource Center ...

This is your complete resource center with news and updates: How to pass your Information Technology Certification exam! Free certification and complete computer examination training, CIW, Microsoft MCTS Certification, comptia and all other Information Technology certifications are achieved by knowing what is on the actual exam and how to retain this knowledge. Lose your fear of test taking. Microsoft and all other knowledge base companies have preparation ebooks that are available on the Internet. You can pass your computer certification exam guaranteed! The schooling involves using relevant study material to the actual examination and using textbooks and study guides that are not outdated. It is also possible to find identical questions that are on the actual accreditation analysis that will help prepare you for taking the test and these questions are the ones you want to use in your studying.

When you are prepared to take your actual IT examination then you can schedule with prometric or pearsonvue online. Here is a tip on purchasing study material: do not buy any study material such as guides or preparation questions that are old because Microsoft, Novell and all others change their material every 3 to 4 months. This will ensure that you will have up to date documents that will help you in passing.

Information technology news and technical data pertaining to certification exam training is the main purpose of this site. Many people do not know the difference between computer training and IT preparation for the final. I would like to inform everyone what the differences are. Computer training is classroom education with scheduled courses or online study about the career field pertaining to information technology. Let me explain! You may want to become a Server Administrator. To begin with you will need some education somewhere in order to be knowledgeable about the subject and maybe acquire a 2 or 4-year degree or receive some online education with a qualified instructor. You may just want to take a few courses and receive a certificate in this field. This would be considered computer training.

Information technology certification exam training is what you need in order to be fully prepared to pass your final test. After computer training you may have a degree or a certificate but you still do not have an official document that is recognized by Microsoft, CIW and Comptia or any other. If you have computer education that qualifies you to be a Server Administrator then you will want to get certified in Microsoft, CIW, MCDST, MCITP Certification or CISCO. Certification exam education concentrates on preparing you to pass your final test. An IT certification assessment is unlike any other analysis that you have had in college or school. There are two very important things to consider when preparing for a certificate test. They are the proper study technique and having relevant material that pertains to the actual exam that is up to date with the current market.

There are only a handful of places online that offer certification exam training. There are many students of information technology that want data on free practice exam questions and free computer training as well as paid because they are serious about passing their official recognition assessment on the very first try. This site is not about selling but about helping those who are not informed about the many different certifications and proper preparation like practice test questions and study guides.

Another purpose of this site is education concerning information technology to obtain a certificate. There are many colleges and online educational sites that will prepare you for a particular subject or field but there are but a few places where you can find information technology certification exam preparation and free IT training.

Say you want to become a PC Technician and you study at a college or receive online training so that you are knowledgeable about that field and receive a diploma or certificate in that area but you still are not certified until you take the final test. Even after graduation you will need to schedule an IT final test with prometric or pearsonvue in order to be certified in the field that you desire.

How many places do you know where you can get the schooling on how to pass your information technology certification exam. This kind of education is not the same as computer training. You will need knowledge of how to study for your certificate test and to know the proper study techniques because an IT assessment is not the same as the exams in school. You will also need to know where to get updated material about your computer certification test because if you have studying material that is outdated then you will not pass.

Certification exam training is important if you plan on passing your on the first time so you can avoid multiple testing fees. Some people may already be working on the job in the profession that they desire, such as a Server Administrator, Desktop Support Technician or a PC Repair Technician. They may have had prior training before employment but have never acquired a certificate. They probably know their job and are very knowledgeable about their work and field but need a certificate because their employer requires it. They do not need any computer education. They only need certification exam preparation so they can pass their final. I hope you get the picture now.

How many places do you know where you can get the schooling on how to pass your information technology certification exam. This kind of education is not the same as computer training. You will need knowledge of how to study for your certificate test and to know the proper study techniques because an IT assessment is not the same as the exams in school. You will also need to know where to get updated material about your computer certification test because if you have studying material that is outdated then you will not pass.

If your preparing for career change and looking for best Microsoft certification like Microsoft sharepoint, Microsoft CRM, MCTS Certification Actualkey.com is the best online training provider that provide the all the and complete MCTS Certification in just one package, Actualkey self study training kits, save your money on bootcamps, training institutes, It's also save your traveling and time. All training materials are Guaranteed to pass your exams and get you certified on the fist attempt, due to best training Actualkey become no1 site

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